The hESC core facility has been established to facilitate the transfer of this technology to the Mount Sinai community and other NY state affiliated institutions.
This collection, from Dr. Thomas Quertermous (Stanford University), was generated with the goal of developing iPS cell lines from several hundred individuals, whose insulin sensitivity is known. The focus is on investigating cellular phenotype through whole genome transcriptome sequencing and assays of insulin signaling. The results may then be used to build a knowledge base of information about type 2 diabetes, insulin resistance, and susceptibility to other cardiovascular disease.
The iPSC lines in this collection were banked and characterized by the Icahn School of Medicine at Mount Sinai Stem Cell Core.
This collection contains over 200 cell lines. Individuals giving rise to iPSC lines were from the Genetics of Insulin Sensitivity (GENESIS) consortium. The paper describing the cohort may be found here. Subjects all reported no disease. Age of donors range from 38-79 years and ethnicities include Caucasian, African American, Asian, Asian/Latino, and Latino.