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Columbia University


Columbia University is one of the world's most important centers of research and at the same time a distinctive and distinguished learning environment for undergraduates and graduate students in many scholarly and professional fields. The University recognizes the importance of its location in New York City and seeks to link its research and teaching to the vast resources of a great metropolis. It seeks to attract a diverse and international faculty and student body, to support research and teaching on global issues, and to create academic relationships with many countries and regions. It expects all areas of the university to advance knowledge and learning at the highest level and to convey the products of its efforts to the world.




  • Single Molecule Dwell-time Distributions ( Software )

    Dwell-time distributions, waiting-time distributions, or distributions of pause durations are widely reported in single molecule biophysical experiments. Simplified models have enabled kinetic analyses of many systems, but they may misrepresent the data if reverse and branching kinetic pathways are present. We have developed a novel computational method that overcomes these limitations and can handle complex kinetic schemes. Furthermore this method can be used to globally fit data under different conditions with a single kinetic scheme. This method was originally developed for the analysis of single molecule dwell-time distributions of myosin V under different concentrations and optical trap forces. Reference: Liao, J.-C., Spudich, J.A., Parker, D., Delp, S.L. (2007) Extending the absorbing boundary method to fit dwell-time distributions of molecular motors with complex kinetic pathways. Proceedings of the National Academy of Sciences, USA, 104, 3171-3716. http://www.pnas.org/cgi/content/abstract/104/9/3171

    Keywords: computational modeling, simulation

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Last updated: 2013-09-23T15:51:17.331-04:00

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