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noRNAlize: SHAPE data normalization software

eagle-i ID


Resource Type

  1. Software


  1. Resource Description
    This project is a data analysis package to analyze and normalize SHAPE data. Traditionally, SHAPE requires the addition of a 3' hairpin to the RNA for normalization. noRNAlize elminates the need for this experimental step by performing a global analysis of the SHAPE data, and establishing mean protection values. This is particularly important when SHAPE analysis is used to map crystal contacts in crystal structures as illustrated here. Keywords: chemical probing, footprinting, molecular biology, RNA folding
  2. Contact
    Laederach, Alain
  3. Contact
    Vicens, Quentin
  4. Used by
    Wadsworth Center
  5. Operating System
Provenance Metadata About This Resource Record

Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016