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eagle-i ID


Resource Type

  1. Software


  1. Resource Description
    "This project contains the AlloPathFinder application that allows users to compute likely allosteric pathways in proteins. The underlying assumption is that residues participating in allosteric communication should be fairly conserved and that communication happens through residues that are close in space. The initial application for the code provided was to study the allosteric communication in myosin. Myosin is a well-studied molecular motor protein that walks along actin filaments to achieve cellular tasks such as movement of cargo proteins. It couples ATP hydrolysis to highly-coordinated conformational changes that result in a power-stroke motion, or ''walking'' of myosin. Communication between a set of residues must link the three functional regions of myosin and transduce energy: the catalytic ATP binding region, the lever arm, and the actin-binding domain. We are investigating which residues are likely to participate in allosteric communication pathways." Keywords: allosteric communication, allostery
  2. Contact
    Tang, Susan
  3. Contact
    Schmidt, Jeanette
  4. Contact
    Liao, Jung-Chi
  5. Contact
    Dunn, Alex
  6. Used by
    Stanford University
  7. Operating System
    Microsoft Windows
  8. Website(s)
Provenance Metadata About This Resource Record

Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016