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Quertermous Lab

Summary:

The Quertermous laboratory is interested in the molecular mechanisms that mediate vascular disease pathophysiology and the risk for these diseases. The approach is primarily genetic, using human cohorts and large scale genome wide studies to identify genes that associate with disease and risk, and molecular genetic studies to define the mechanisms of these associations. At the human level, we collaborate with a number of centers around the world through the CARDIoGRAM+C4D consortium to further identify coronary heart disease loci, and our group serves as the the organizing center searching for loci that associate with gold standard measures of insulin sensitivity, the GENESIS study. For loci identified through these studies, we work to identify mechanisms by which causal variation is responsible for altered gene structure or function, and employ cellular and genetic mouse models to identify how encoded factors participate in the disease process. One novel approach to understanding the link between genes and human disease is employing induced pluripotent stem cells to create disease relevant cell types in vitro that can be studied in relationship to the subjects' phenotype and genetic architecture.

Affiliations:

People:

Resources:

Human Studies

  • IDENTIFYING THE GENE NETWORKS OF INSULIN RESISTANCE: THE GENESIPS STUDY ( Human Study )

    The normal action of insulin to promote glucose disposal varies over 600% in the population, with those individuals who are least sensitive to insulin having to mount sustained increased levels to maintain optimum serum glucose levels. Some of these individuals develop type 2 diabetes mellitus (DM2), but even those who do not develop DM2 are at increased risk for dyslipidemia, hypertension and atherosclerotic cardiovascular disease. While up to a third of the US population has this insulin resistance (IR) syndrome, our ability to identify individuals with (or at risk) for IR is extremely limited, and there are few treatment options for IR. Insulin sensitivity (IS) is largely determined at the genetic level, with heritability estimated at -50%. To aid in the search for genetic variation that underlies the extreme variance in IS, and the pathophysiology of IR, we are performing genome-wide association study of all individuals in the world phenotyped by insulin clamp measures of IS, through the Genetics of Insulin Sensitivity (GENESIS-2) consortium. Further insights into the cellular and molecular basis of IR could be gained through the study of metabolic and vascular cells from subjects with known insulin sensitivity and genetic architecture. Toward this end, we propose here to develop induced pluripotent cell (iPSC) lines from several hundred individuals of the GENESIS-2 cohort, as a sustainable resource for the production of metabolic and vascular cells in culture, the Genetics of Insulin Sensitivity iPSC (GENESiPS) study. We will develop methods for optimized differentiation of iPSC to the skeletal muscle (or adipose) and vascular endothelial cell lineages. The cellular phenotype of these cells will be investigated through whole genome transcriptome sequencing, as well as cell-based assays of insulin signaling and action. By combining the known human IS phenotype and whole genome variation with the differentiated cellular phenotypes at baseline and in response to insulin stimulation, we will undertake a systems biology approach to defining the cellular IR phenotype. These analyses will leverage novel network approaches that improve power, and provide added insights into the genes and pathways that may be targeted for the development of next generation insulin sensitizing therapies.

Reagents

  • STAN076i-004C1 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 197
    Group: Insulin Resistant

  • STAN077i-004C2 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 197
    Group: Insulin Resistant

  • STAN078i-018C2 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 180
    Group: Intermediate

  • STAN079i-018C3 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 180
    Group: Intermediate

  • STAN080i-023C2 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 142
    Group: Intermediate

  • STAN081i-023C3 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 142
    Group: Intermediate

  • STAN082i-024C1 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 153
    Group: Intermediate

  • STAN083i-024C4 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 153
    Group: Intermediate

  • STAN084i-041C1 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 108
    Group: Intermediate

  • STAN085i-041C3 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 108
    Group: Intermediate

  • STAN086i-054C1 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 145
    Group: Intermediate

  • STAN087i-054C2 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 145
    Group: Intermediate

  • STAN088i-060C1 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 196
    Group: Insulin Resistant

  • STAN089i-070C2 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 267
    Group: Insulin Resistant

  • STAN090i-070C4 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 267
    Group: Insulin Resistant

  • STAN091i-071C2 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 77
    Group: Insulin Sensitive

  • STAN093i-081C1 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 171
    Group: Intermediate

  • STAN094i-081C2 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 171
    Group: Intermediate

  • STAN095i-102C4 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 136
    Group: Intermediate

  • STAN096i-102C6 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 136
    Group: Intermediate

  • STAN097i-107C3 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 66
    Group: Insulin Sensitive

  • STAN098i-107C4 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 66
    Group: Insulin Sensitive

  • STAN099i-108C2 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 88
    Group: Insulin Sensitive

  • STAN100i-108C4 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 88
    Group: Insulin Sensitive

  • STAN104i-120C3 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 129
    Group: Intermediate

  • STAN106i-121C1 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 233
    Group: Insulin Resistant

  • STAN107i-121C2 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 233
    Group: Insulin Resistant

  • STAN108i-123C2 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 174
    Group: Intermediate

  • STAN109i-123C3 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 174
    Group: Intermediate

  • STAN111i-125C4 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 186
    Group: Intermediate

  • STAN114i-135C2 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 98
    Group: Insulin Sensitive

  • STAN115i-148C2 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 266
    Group: Insulin Resistant

  • STAN116i-148C4 ( Induced pluripotent stem cell line )

  • STAN117i-182C4 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 280
    Group: Insulin Resistant

  • STAN118i-182C7 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 280
    Group: Insulin Resistant

  • STAN119i-192C1 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 103
    Group: Insulin Sensitive

  • STAN120i-192C2 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 103
    Group: Insulin Sensitive

  • STAN121i-193C2 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 255
    Group: Insulin Resistant

  • STAN122i-193C1 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 255
    Group: Insulin Resistant

  • STAN125i-202C2 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 181
    Group: Intermediate

  • STAN126i-202C3 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 181
    Group: Intermediate

  • STAN128i-211C2 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 80
    Group: Insulin Sensitive

  • STAN129i-212C2 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 141
    Group: Intermediate

  • STAN130i-212C4 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 141
    Group: Intermediate

  • STAN131i-214C3 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 53
    Group: Insulin Sensitive

  • STAN132i-214C4 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 53
    Group: Insulin Sensitive

  • STAN133i-215C1 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 91
    Group: Insulin Sensitive

  • STAN134i-215C2 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 91
    Group: Insulin Sensitive

  • STAN135i-230C1 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 95
    Group: Insulin Sensitive

  • STAN136i-230C2 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 95
    Group: Insulin Sensitive

  • STAN137i-231C3 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 245
    Group: Insulin Resistant

  • STAN138i-239C3 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 272
    Group: Insulin Resistant

  • STAN139i-239C5 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 272
    Group: Insulin Resistant

  • STAN140i-243C1 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 209
    Group: Insulin Resistant

  • STAN141i-250C4 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 187
    Group: Intermediate

  • STAN142i-255C1 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 323
    Group: Insulin Resistant

  • STAN144i-285C3 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 147
    Group: Intermediate

  • STAN145i-286C1 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 67
    Group: Insulin Sensitive

  • STAN146i-286C2 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 67
    Group: Insulin Sensitive

  • STAN148i-291C3 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 94
    Group: Insulin Sensitive

  • STAN149i-298C1 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 145
    Group: Intermediate

  • STAN150i-337C1 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 145
    Group: Intermediate

  • STAN151i-303C3 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 163
    Group: Intermediate

  • STAN152i-307C2 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 199
    Group: Insulin Resistant

  • STAN153i-307C3 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 199
    Group: Insulin Resistant

  • STAN154i-312C1 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 85
    Group: Insulin Sensitive

  • STAN155i-313C2 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 114
    Group: Intermediate

  • STAN156i-334C1 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 115
    Group: Intermediate

  • STAN157i-334C2 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 115
    Group: Intermediate

  • STAN158i-336C2 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 243
    Group: Insulin Resistant

  • STAN159i-336C3 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 243
    Group: Insulin Resistant

  • STAN160i-341C4 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 175
    Group: Intermediate

  • STAN161i-341C5 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 175
    Group: Intermediate

  • STAN162i-345C2 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 50
    Group: Insulin Sensitive

  • STAN163i-345C5 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 50
    Group: Insulin Sensitive

  • STAN164i-352C1 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 100
    Group: Insulin Sensitive

  • STAN165i-352C5 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 100
    Group: Insulin Sensitive

  • STAN166i-356C4 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 73
    Group: Insulin Sensitive

  • STAN167i-356C6 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 73
    Group: Insulin Sensitive

  • STAN168i-358C1 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 212
    Group: Insulin Resistant

  • STAN169i-358C4 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 212
    Group: Insulin Resistant

  • STAN170i-364C3 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 54
    Group: Insulin Sensitive

  • STAN171i-364C4 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 54
    Group: Insulin Sensitive

  • STAN173i-368C2 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 217
    Group: Insulin Resistant

  • STAN174i-371C3 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 73
    Group: Insulin Sensitive

  • STAN175i-373C4 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 165
    Group: Intermediate

  • STAN176i-373C6 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 165
    Group: Intermediate

  • STAN179i-400C2 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 133
    Group: Intermediate

  • STAN180i-408C2 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 253
    Group: Insulin Resistant

  • STAN181i-408C4 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 253
    Group: Insulin Resistant

  • STAN182i-410C3 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 61
    Group: Insulin Sensitive

  • STAN183i-410C4 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 61
    Group: Insulin Sensitive

  • STAN187i-420C6 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 67
    Group: Insulin Sensitive

  • STAN190i-424C2 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 236
    Group: Insulin Resistant

  • STAN191i-429C2 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 130
    Group: Intermediate

  • STAN192i-429C3 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 130
    Group: Intermediate

  • STAN193i-432C1 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 157
    Group: Intermediate

  • STAN194i-432C3 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 157
    Group: Intermediate

  • STAN195i-434C3 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 200
    Group: Insulin Resistant

  • STAN197i-411C1 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 63
    Group: Insulin Sensitive

  • STAN198i-441C2 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 63
    Group: Insulin Sensitive

  • STAN200i-444C1 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 202
    Group: Insulin Resistant

  • STAN201i-444C2 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 202
    Group: Insulin Resistant

  • STAN202i-445C1 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 104
    Group: Insulin Sensitive

  • STAN203i-445C2 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 104
    Group: Insulin Sensitive

  • STAN204i-448C1 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 145
    Group: Intermediate

  • STAN205i-448C2 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 145
    Group: Intermediate

  • STAN206i-459C1 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 93
    Group: Insulin Sensitive

  • STAN207i-459C2 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 93
    Group: Insulin Sensitive

  • STAN208i-460C2 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 163
    Group: Intermediate

  • STAN209i-460C6 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 163
    Group: Intermediate

  • STAN210i-468C1 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 138
    Group: Intermediate

  • STAN211i-475C1 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 69
    Group: Insulin Sensitive

  • STAN212i-488C2 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 120
    Group: Intermediate

  • STAN213i-488C3 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 120
    Group: Intermediate

  • STAN216i-496C1 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 199
    Group: Insulin Resistant

  • STAN217i-496C2 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 199
    Group: Insulin Resistant

  • STAN218i-501C5 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 142
    Group: Intermediate

  • STAN219i-501C6 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 142
    Group: Intermediate

  • STAN220i-504C2 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 92
    Group: Insulin Sensitive

  • STAN222i-509C2 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 69
    Group: Insulin Sensitive

  • STAN223i-509C3 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 69
    Group: Insulin Sensitive

  • STAN224i-514C3 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 173
    Group: Intermediate

  • STAN225i-514C4 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 173
    Group: Intermediate

  • STAN226i-516C3 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 57
    Group: Insulin Sensitive

  • STAN227i-516C5 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 57
    Group: Insulin Sensitive

  • STAN228i-523C1 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 215
    Group: Insulin Resistant

  • STAN229i-523C2 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 215
    Group: Insulin Resistant

  • STAN230i-533C1 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 193
    Group: Insulin Resistant

  • STAN231i-533C2 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 193
    Group: Insulin Resistant

  • STAN232i-541C2 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 60
    Group: Insulin Sensitive

  • STAN233i-541C5 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 60
    Group: Insulin Sensitive

  • STAN234i-546C1 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 202
    Group: Insulin Resistant

  • STAN235i-546C2 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 202
    Group: Insulin Resistant

  • STAN236i-551C1 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 282
    Group: Insulin Resistant

  • STAN237i-551C2 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 282
    Group: Insulin Resistant

  • STAN238i-553C5 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 48
    Group: Insulin Sensitive

  • STAN239i-553C8 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 48
    Group: Insulin Sensitive

  • STAN240i-558C3 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 171
    Group: Intermediate

  • STAN241i-558C4 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 171
    Group: Intermediate

  • STAN242i-573C2 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 257
    Group: Insulin Resistant

  • STAN243i-589C3 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 260
    Group: Insulin Resistant

  • STAN244i-589C4 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 260
    Group: Insulin Resistant

  • STAN245i-601C4 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 161
    Group: Intermediate

  • STAN246i-601C5 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 161
    Group: Intermediate

  • STAN247i-614C2 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 117
    Group: Intermediate

  • STAN248i-617C1 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 105
    Group: Insulin Sensitive

  • STAN249i-617C2 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 105
    Group: Insulin Sensitive

  • STAN250i-622C2 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 175
    Group: Intermediate

  • STAN251i-637C1 ( Induced pluripotent stem cell line )

  • STAN252i-637C2 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 168
    Group: Intermediate

  • STAN253i-647C1 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 235
    Group: Insulin Resistant

  • STAN254i-647C3 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 235
    Group: Insulin Resistant

  • STAN255i-649C1 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 106
    Group: Insulin Sensitive

  • STAN256i-649C2 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 106
    Group: Insulin Sensitive

  • STAN257i-685C3 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 132
    Group: Intermediate

  • STAN258i-685C4 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 132
    Group: Intermediate

  • STAN259i-688C1 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 279
    Group: Insulin Resistant

  • STAN260i-688C3 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 279
    Group: Insulin Resistant

  • STAN261i-698C5 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 66
    Group: Insulin Sensitive

  • STAN263i-703C1 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 231
    Group: Insulin Resistant

  • STAN264i-703C2 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 231
    Group: Insulin Resistant

  • STAN265i-707C1 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 76
    Group: Insulin Sensitive

  • STAN266i-707C4 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 76
    Group: Insulin Sensitive

  • STAN269i-720C2 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 49
    Group: Insulin Sensitive

  • STAN270i-720C3 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 49
    Group: Insulin Sensitive

  • STAN271i-726C3 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 251
    Group: Insulin Resistant

  • STAN272i-726C4 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 251
    Group: Insulin Resistant

  • STAN273i-729C1 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 244
    Group: Insulin Resistant

  • STAN274i-729C2 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 244
    Group: Insulin Resistant

  • STAN275i-732C1 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 248
    Group: Insulin Resistant

  • STAN276i-756C4 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 60
    Group: Insulin Sensitive

  • STAN277i-756C5 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 60
    Group: Insulin Sensitive

  • STAN278i-767C2 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 178
    Group: Intermediate

  • STAN279i-767C3 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 178
    Group: Intermediate

  • STAN280i-770C1 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 138
    Group: Intermediate

  • STAN281i-770C2 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 138
    Group: Intermediate

  • STAN282i-771C3 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 173
    Group: Intermediate

  • STAN283i-771C4 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 173
    Group: Intermediate

  • STAN284i-780C1 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 82
    Group: Insulin Sensitive

  • STAN285i-780C2 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 82
    Group: Insulin Sensitive

  • STAN286i-799C2 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 89
    Group: Insulin Sensitive

  • STAN287i-810C1 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 106
    Group: Insulin Sensitive

  • STAN288i-810C3 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 106
    Group: Insulin Sensitive

  • STAN291i-827C1 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 181
    Group: Intermediate

  • STAN292i-827C2 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 181
    Group: Intermediate

  • STAN293i-835C1 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 70
    Group: Insulin Sensitive

  • STAN294i-835C5 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 70
    Group: Insulin Sensitive

  • STAN295i-836C1 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 81
    Group: Insulin Sensitive

  • STAN296i-836C2 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 81
    Group: Insulin Sensitive

  • STAN297i-839C1 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 200
    Group: Insulin Resistant

  • STAN298i-839C5 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 200
    Group: Insulin Resistant

  • STAN299i-843C5 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 153
    Group: Intermediate

  • STAN300i-843C6 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 153
    Group: Intermediate

  • STAN301i-845AC2 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 76
    Group: Insulin Sensitive

  • STAN302i-845AC4 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 76
    Group: Insulin Sensitive

  • STAN303i-864C2 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 43
    Group: Insulin Sensitive

  • STAN304i-864C5 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 43
    Group: Insulin Sensitive

  • STAN305i-865C2 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 235
    Group: Insulin Resistant

  • STAN306i-865C3 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 235
    Group: Insulin Resistant

  • STAN307i-871C2 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 202
    Group: Insulin Resistant

  • STAN308i-871C3 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 202
    Group: Insulin Resistant

  • STAN311i-906C1 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 136
    Group: Intermediate

  • STAN312i-906C3 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 136
    Group: Intermediate

  • STAN313i-907C1 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 103
    Group: Insulin Sensitive

  • STAN314i-907C4 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 103
    Group: Insulin Sensitive

  • STAN315i-909C1 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 75
    Group: Insulin Sensitive

  • STAN316i-909C2 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 75
    Group: Insulin Sensitive

  • STAN317i-910C2 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 90
    Group: Insulin Sensitive

  • STAN318i-910C3 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 90
    Group: Insulin Sensitive

  • STAN319i-922C1 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 207
    Group: Insulin Resistant

  • STAN321i-924C1 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 172
    Group: Intermediate

  • STAN322i-924C2 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 172
    Group: Intermediate

  • STAN323i-928C2 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 201
    Group: Insulin Resistant

  • STAN324i-928C6 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 201
    Group: Insulin Resistant

  • STAN327i-940C2 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 103
    Group: Insulin Sensitive

  • STAN328i-946C2 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 212
    Group: Insulin Resistant

  • STAN329i-949C3 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 208
    Group: Insulin Resistant

  • STAN330i-949C4 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 208
    Group: Insulin Resistant

  • STAN331i-952C3 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 82
    Group: Insulin Sensitive

  • STAN332i-952C5 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 82
    Group: Insulin Sensitive

  • STAN333i-955C1 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 82
    Group: Insulin Sensitive

  • STAN334i-955C2 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 82
    Group: Insulin Sensitive

  • STAN336i-963C1 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 258
    Group: Insulin Resistant

  • STAN337i-963C3 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 258
    Group: Insulin Resistant

  • STAN338i-975C1 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 84
    Group: Insulin Sensitive

  • STAN339i-975C3 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 84
    Group: Insulin Sensitive

  • STAN340i-981C1 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 112
    Group: Intermediate

  • STAN341i-994C1 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 102
    Group: Insulin Sensitive

  • STAN342i-994C3 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 102
    Group: Insulin Sensitive

  • STAN343i-998C1 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 102
    Group: Insulin Sensitive

  • STAN345i-390C3 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 102
    Group: Insulin Sensitive

  • STAN346i-59C2 ( Induced pluripotent stem cell line )

  • STAN347i-66C3 ( Induced pluripotent stem cell line )

  • STAN348i-851C1 ( Induced pluripotent stem cell line )

  • STAN349i-762C3 ( Induced pluripotent stem cell line )

  • STAN350i-694C5 ( Induced pluripotent stem cell line )

    Steady-State Plasma Glucose Levels: 90
    Group: Insulin Sensitive

  • STAN351i-631C1 ( Induced pluripotent stem cell line )

  • STAN357i-298C2 ( Induced pluripotent stem cell line )

  • STAN358i-298C3 ( Induced pluripotent stem cell line )

  • STAN359i-442C11 ( Induced pluripotent stem cell line )

  • STAN360i-465C2 ( Induced pluripotent stem cell line )

  • STAN361i-531C6 ( Induced pluripotent stem cell line )

  • STAN362i-178C1 ( Induced pluripotent stem cell line )

  • STAN363i-845C5 ( Induced pluripotent stem cell line )

  • STAN364i-055C2 ( Induced pluripotent stem cell line )

  • STAN365i-664C1 ( Induced pluripotent stem cell line )

  • STAN366i-282C2 ( Induced pluripotent stem cell line )

  • STAN367i-894C1 ( Induced pluripotent stem cell line )

  • STAN368i-894C2 ( Induced pluripotent stem cell line )

  • STAN369i-088C3 ( Induced pluripotent stem cell line )

  • STAN370i-190C3 ( Induced pluripotent stem cell line )

  • STAN371i-868C5 ( Induced pluripotent stem cell line )

  • STAN372i-411C8 ( Induced pluripotent stem cell line )

  • STAN373i-412C4 ( Induced pluripotent stem cell line )

  • STAN374i-565C4 ( Induced pluripotent stem cell line )

  • STAN375i-961C1 ( Induced pluripotent stem cell line )

  • STAN376i-518C2 ( Induced pluripotent stem cell line )

  • STAN377i-572C5 ( Induced pluripotent stem cell line )

  • STAN378i-886C4 ( Induced pluripotent stem cell line )

  • STAN379i-783C6 ( Induced pluripotent stem cell line )

  • STAN380i-092C2 ( Induced pluripotent stem cell line )

  • STAN381i-652C1 ( Induced pluripotent stem cell line )

Resource Collection

  • (WiCell) Insulin Resistance Syndrome Collection - Quertermous Lab ( Resource Collection )

    This collection, from Dr. Thomas Quertermous (Stanford University), was generated with the goal of developing iPS cell lines from several hundred individuals, whose insulin sensitivity is known. The focus is on investigating cellular phenotype through whole genome transcriptome sequencing and assays of insulin signaling. The results may then be used to build a knowledge base of information about type 2 diabetes, insulin resistance, and susceptibility to other cardiovascular disease.

    The iPSC lines in this collection were banked and characterized by the Icahn School of Medicine at Mount Sinai Stem Cell Core.

    This collection contains over 200 cell lines. Individuals giving rise to iPSC lines were from the Genetics of Insulin Sensitivity (GENESIS) consortium. The paper describing the cohort may be found here. Subjects all reported no disease. Age of donors range from 38-79 years and ethnicities include Caucasian, African American, Asian, Asian/Latino, and Latino.


Web Links:

Last updated: 2017-05-19T15:12:28.513-05:00

Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016