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Goldstein Lab

Summary:

The primary goals in the Goldstein lab are to unravel how molecular motors interact with, and control the behavior of, axonal vesicles, and to relate this understanding to the molecular basis of neuronal defects in Alzheimer's Disease (AD) and Niemann Pick type C disease.

Affiliations:

People:

    Resources:

    Human Studies

    Reagents

    • UCSD223i-NDC1-1 ( Induced pluripotent stem cell line )

      Non-Demented Control

    • UCSD224i-NDC1-2 ( Induced pluripotent stem cell line )

      Non-Demented Control

    • UCSD225i-NDC1-3 ( Induced pluripotent stem cell line )

      Non-Demented Control

    • UCSD226i-NDC2-1 ( Induced pluripotent stem cell line )

      Non-Demented Control

    • UCSD227i-NDC2-2 ( Induced pluripotent stem cell line )

      Non-Demented Control

    • UCSD228i-NDC2-3 ( Induced pluripotent stem cell line )

      Non-Demented Control

    • UCSD229i-SAD1-1 ( Induced pluripotent stem cell line )

      Sporadic Alzheimer Disease

    • UCSD230i-SAD1-2 ( Induced pluripotent stem cell line )

      Sporadic Alzheimer Disease

    • UCSD231i-SAD1-3 ( Induced pluripotent stem cell line )

      Sporadic Alzheimer Disease

    • UCSD232i-SAD2-1 ( Induced pluripotent stem cell line )

      Sporadic Alzheimer Disease

    • UCSD233i-SAD2-2 ( Induced pluripotent stem cell line )

      Sporadic Alzheimer Disease

    • UCSD234i-SAD2-3 ( Induced pluripotent stem cell line )

      Sporadic Alzheimer Disease

    • UCSD235i-SAD2-4 ( Induced pluripotent stem cell line )

      Sporadic Alzheimer Disease

    • UCSD236i-APP1-1 ( Induced pluripotent stem cell line )

      Familial Alzheimer Disease

    • UCSD237i-APP1-2 ( Induced pluripotent stem cell line )

      Familial Alzheimer Disease

    • UCSD238i-APP1-3 ( Induced pluripotent stem cell line )

      Familial Alzheimer Disease

    • UCSD239i-APP2-1 ( Induced pluripotent stem cell line )

      Familial Alzheimer Disease

    • UCSD240i-APP2-2 ( Induced pluripotent stem cell line )

      Familial Alzheimer Disease

    • UCSD241i-APP2-3 ( Induced pluripotent stem cell line )

      Familial Alzheimer Disease

    Resource Collection

    • (WiCell) Alzheimer's Disease Collection ( Resource Collection )

      Alzheimer’s disease pathogenesis investigation has historically been limited by difficulties in obtaining live neurons from patients and the inability to model the sporadic form of the disease. In an effort to overcome these hurdles, primary fibroblasts were isolated and reprogrammed into iPS cell lines from two patients with familial Alzheimer’s disease, both caused by a duplication of the amyloid-β precursor protein gene1 (APP; termed APPDp); two with sporadic Alzheimer’s disease (termed sAD1, sAD2); and two non-demented control individuals. A total of 19 iPS cell lines were derived from materials obtained from these individuals.


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    Last updated: 2016-07-28T14:40:11.956-05:00

    Copyright © 2016 by the President and Fellows of Harvard College
    The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016