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Frazer Lab

Summary:

Located in the Leichtag Biomedical Research Building on UCSD’s main campus, the Frazer Laboratory’s research focuses on the genetics and functional genomics of cardiovascular diseases and cancer. Our research mission is to identify common and rare genetic variants that are associated with human disease in order to functionally assess their role in disease pathogenesis, progression, and prognosis. With our discoveries we hope to accelerate the translation of genomic research into clinical therapies and applications.

Affiliations:

People:

Resources:

Human Studies

  • REGULATORY GENOMIC STUDIES IN A COHORT OF IPS CELL DERIVED CARDIOMYOCYTES ( Human Study )

    "The overarching goal of our project is to use IPSC derived cardiomyocytes from genotyped individuals as cellular models to investigate how human genetic variation influences the gene regulatory networks Involved In cardiac biology and disease. Despite current treatment regimens, cardiovascular diseases remain the leading cause of morbidity and mortality in the United States and developed countries. Genome-wide association studies have identified a number of loci associated with cardiovascular disease susceptibility. Our Study will clarify the functional significance of these findings by combining cellular reprogramming Strategies with integrated molecular profiling and cellular assays. We have assembled a team of highly accomplished researchers in stem cell biology, cardiac cell biology, genomics, molecular genetics/epigenetics, biostatistics, and clinical medicine, and are well positioned to achieve the project goals within five years. After collecting fibroblasts and keratinocytes from individuals in the UCSD TSP cohort, the project will be carried out in three phases. In PHASE I, we will establish standardized reagents and procedures for the generation of iPSCs. Additionally, we will take advantage of our ongoing research efforts to increase the efficiency of cardiomyocyte differentiation to 80%, a substantial increase over current protocols (~20%). In PHASE II, we will develop cutting-edge technologies for high throughput generation of IPSCs, which will enable us to generate 600 iPSC lines (3 lines each from 200 individuals) in ~ 24 months. We will also scale our optimized protocols for deriving cardiomyocytes from the IPSC lines. In PHASE III we will initially perform validation experiments to measure the genomic profile variability between isogenic (derived from the same individual) cardiomyocytes. We will then use the derived cardiomyocytes to 1) Identify and characterize the causal DNA variants underlying strong GWAS signals with electrocardiographic traits; and 2) Identify expressed quantitative traits loci (eQTL) in the cohort of IPSC derived cardiomyocytes at baseline (untreated) and after stimulation."

Reagents

  • UCSD001i-5-1 ( Induced pluripotent stem cell line )

    Cardiomyopathy (Hypertrophic)
    dbGaP iPSC UUID: d6426eb1d8c74352b0d18785820f0ebb

  • UCSD002i-16-1 ( Induced pluripotent stem cell line )

    dbGaP iPSC UUID: e7a035161a5a4739a57db0570e5f898d

  • UCSD003i-16-2 ( Induced pluripotent stem cell line )

    Danon disease, Hypothyroidism
    dbGaP iPSC UUID: e5bc2cdb6047428887860ba08df7dc89

  • UCSD004i-42-1 ( Induced pluripotent stem cell line )

    Left ventricular non-compaction
    dbGaP iPSC UUID: b5f1659be2db4333bc3fc4e85b406d60

  • UCSD005i-43-1 ( Induced pluripotent stem cell line )

    Left ventricular non-compaction
    dbGaP iPSC UUID: a1dc93319ed24d8e98a44aa57e92c67f

  • UCSD006i-21-1 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: 01351a7147854b52b27017ee3a000af0

  • UCSD007i-21-2 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: 7673a09dcd1541938439d9747d306b97

  • UCSD008i-44-1 ( Induced pluripotent stem cell line )

    Left ventricular non-compaction
    dbGaP iPSC UUID: d4ed4dabca7f40e69bcfefb10aa5e912

  • UCSD009i-5-2 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: e14c40862e9c4149bfe175b61ed1cf03

  • UCSD010i-5-3 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: 58a1c8539d524c7dbc03d0886c169483

  • UCSD011i-5-4 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: 7d57a77bf2064bd5b1be5e0e6c635406

  • UCSD012i-5-5 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: fa63c8f9fc7f4892a94cc249617b55f0

  • UCSD013i-16-3 ( Induced pluripotent stem cell line )

    Danon disease
    dbGaP iPSC UUID: 3889851ed91b42d493286defbb16b019

  • UCSD014i-21-3 ( Induced pluripotent stem cell line )

    Cardiomyopathy (dilated)
    dbGaP iPSC UUID: 328b3d3b3e354a1492c169337f04d53f

  • UCSD015i-3-3 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: 9776da372e28418cbf7f63448155e613

  • UCSD016i-3-4 ( Induced pluripotent stem cell line )

    Premature ventricular contractions
    dbGaP iPSC UUID: 9e2eac0aed8a43b796c7dce3e57d62b2

  • UCSD017i-3-5 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: 7f05bb5295c84e5da2010b67b797bd76

  • UCSD018i-3-6 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: dfe586bd8c2440de825c3cc619054169

  • UCSD019i-3-7 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: 6ca9f47754e14ce6b7d31a0e0eb55466

  • UCSD020i-3-8 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: be09429383a945f1b86b14cec0753c4b

  • UCSD021i-3-9 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: 3e2934b33fbf4639968fc6abbc8ec6a1

  • UCSD022i-8-3 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: 68ad20ddc3174da59ec8dea00e7f3eee

  • UCSD023i-8-4 ( Induced pluripotent stem cell line )

    Bells Palsy
    dbGaP iPSC UUID: d903693d3be54763a405850596484ec6

  • UCSD024i-13-3 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: 44a4feabf4ac42db8c6e2d0c5f7561b0

  • UCSD025i-13-4 ( Induced pluripotent stem cell line )

    Neuropathy
    dbGaP iPSC UUID: 148515761a2d402cb40128558480089b

  • UCSD026i-9-1 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: bbe62d3176264700b68b7c7438f6fc18

  • UCSD027i-9-2 ( Induced pluripotent stem cell line )

    Brain tumor
    dbGaP iPSC UUID: c93aac18977f4a50b711cf5dfe35873c

  • UCSD028i-9-3 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: 95b18c63c6e844cfa5ae7f519e4d0855

  • UCSD029i-9-4 ( Induced pluripotent stem cell line )

    Breast cancer
    dbGaP iPSC UUID: 7d5ba701a6074f509bedb8c97ae373c5

  • UCSD030i-23-2 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: e94de898266446b3b52b27f09cb8969b

  • UCSD031i-45-1 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: e45109ae7a2a47a8b7988c86d90f9383

  • UCSD032i-41-1 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: dea2aebd7fde43c9b6e63d1ac635c6f4

  • UCSD033i-41-2 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: 7eeec928a19a4034bdfc5da8e17e8b8d

  • UCSD034i-4-3 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: c4f3f0f065af4647b66a92cd6ed507ca

  • UCSD035i-4-4 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: e468ececa9194e898b54f38b5d79bbab

  • UCSD036i-4-5 ( Induced pluripotent stem cell line )

    High cholesterol, Gout
    dbGaP iPSC UUID: 38d53c6d29f0402fbc2d32adc0bbf220

  • UCSD037i-26-2 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: c993620c6c5746748a84da2432086a23

  • UCSD038i-24-2 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: bb857106e013483baa8ef0cd9d3243e6

  • UCSD039i-14-3 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: 10904b64061a415695b5bf9903398f29

  • UCSD040i-33-1 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: d62a71f74bb249209e96b6fb5df40214

  • UCSD041i-33-2 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: c7c08c01eb7c4b5d88fd34ab6023057d

  • UCSD042i-46-1 ( Induced pluripotent stem cell line )

    Ventricular tachycardia, Atrial septal defect
    dbGaP iPSC UUID: a8165ba0e5454e93bddd0c0e47064d4a

  • UCSD043i-47-1 ( Induced pluripotent stem cell line )

    Atrial Fibrillation
    dbGaP iPSC UUID: 0fbd9cb4095d4e4ea072f4a287431c06

  • UCSD044i-48-1 ( Induced pluripotent stem cell line )

    Long QT Syndrome, Atrial fibrillation
    dbGaP iPSC UUID: 01df4176628b472caafe8cb4878e288f

  • UCSD045i-49-1 ( Induced pluripotent stem cell line )

    Atrial fibrillation
    dbGaP iPSC UUID: 1cc59384fabf4fbca9060c4c5ccba1b5

  • UCSD046i-50-1 ( Induced pluripotent stem cell line )

    Atrial fibrillation
    dbGaP iPSC UUID: 9de465da1c46484c9e7e84ca6ac98dc1

  • UCSD047i-51-1 ( Induced pluripotent stem cell line )

    Atrial fibrillation, Ventricular tachycardia
    dbGaP iPSC UUID: cd73447a59734d0aa91c4d183ab66854

  • UCSD048i-52-1 ( Induced pluripotent stem cell line )

    Coronary artery disease, Atrial fibrillation, Prolonged QT on sotalol
    dbGaP iPSC UUID: 834c008b3d6e484096f1972807855410

  • UCSD049i-53-1 ( Induced pluripotent stem cell line )

    Atrial Fibrillation
    dbGaP iPSC UUID: 51af0c595d9a4553a4aa878cc64f073e

  • UCSD050i-54-1 ( Induced pluripotent stem cell line )

    Atrial Fibrillation
    dbGaP iPSC UUID: 50f5f053b622453e8ff6ebb785d34595

  • UCSD051i-55-1 ( Induced pluripotent stem cell line )

    Atrial Fibrillation
    dbGaP iPSC UUID: a54e68d92da84e1c80d1f06be1f63fad

  • UCSD052i-56-1 ( Induced pluripotent stem cell line )

    Atrial Fibrillation
    dbGaP iPSC UUID: 47326954aed343859c2eb80ce3ac226f

  • UCSD053i-57-1 ( Induced pluripotent stem cell line )

    Atrial Fibrillation
    dbGaP iPSC UUID: 8c5b533be72a449295780e27f341a50f

  • UCSD054i-58-1 ( Induced pluripotent stem cell line )

    Atrial Fibrillation
    dbGaP iPSC UUID: 17c2b6b5c6a544fbb2647cd23c254534

  • UCSD055i-59-1 ( Induced pluripotent stem cell line )

    Cardiomyopathy (Doxorubicin-induced), Thalassemia trait, Breast cancer
    dbGaP iPSC UUID: 7ebf3d3518e2460f8cc67b1cbbafa658

  • UCSD056i-60-1 ( Induced pluripotent stem cell line )

    Cardiomyopathy, ventricular tachycardia, NIDDM
    dbGaP iPSC UUID: 0484f83ba79a4390b6a443f62771e18f

  • UCSD057i-61-1 ( Induced pluripotent stem cell line )

    Atrial Fibrillation, Type II Diabetes, Squamous cell cancer
    dbGaP iPSC UUID: ea17fe9b69da45019c7e6af7aac1b111

  • UCSD058i-62-1 ( Induced pluripotent stem cell line )

    Ventricular tachycardia
    dbGaP iPSC UUID: 55b460bcb58e4e469f359770f05b165b

  • UCSD059i-63-1 ( Induced pluripotent stem cell line )

    Atrial Fibrillation
    dbGaP iPSC UUID: 68bccd4f3531428eb47df6eaa4512d7b

  • UCSD060i-64-1 ( Induced pluripotent stem cell line )

    Premature ventricular contractions
    dbGaP iPSC UUID: 5e96f9e12a14499791c36a43c43de1c6

  • UCSD061i-65-1 ( Induced pluripotent stem cell line )

    Congestive heart failure, Duchenne's muscular dystrophy
    dbGaP iPSC UUID: 00cfe6afa475436f89dfd25416545734

  • UCSD062i-66-1 ( Induced pluripotent stem cell line )

    Long QT Syndrome
    dbGaP iPSC UUID: 9f47bc0cbf5043efa9d2ea44415cfb78

  • UCSD063i-20-1 ( Induced pluripotent stem cell line )

    Narrow angle glaucoma
    dbGaP iPSC UUID: a3ff3d4e44c84b29b97811dedfa462dd

  • UCSD064i-20-2 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: d9644b8439d64a5091bd26e1adea72bf

  • UCSD065i-20-3 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: 1448a1ac8fd44b81b465f3762e10c4e9

  • UCSD066i-67-1 ( Induced pluripotent stem cell line )

    Thyroid cancer
    dbGaP iPSC UUID: a1e36b2172944c0694a1b6af038b4b14

  • UCSD067i-19-1 ( Induced pluripotent stem cell line )

    Hypothyroidism
    dbGaP iPSC UUID: 48524ebf3be54872b7a85423fe105f69

  • UCSD068i-19-2 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: d73ba98d276549a29142735fca6f233f

  • UCSD069i-19-3 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: 0e7ec423d475476bbd886c8b0eea0d6c

  • UCSD070i-1-1 ( Induced pluripotent stem cell line )

    High cholesterol, previously hypothyroid
    dbGaP iPSC UUID: ee4a12081cec479b803fc4a76935b27e

  • UCSD071i-1-2 ( Induced pluripotent stem cell line )

    High cholesterol, hypothyroidism
    dbGaP iPSC UUID: a35cd47edea5442b8bad419c5bdce1c2

  • UCSD072i-1-3 ( Induced pluripotent stem cell line )

    Non-affected Control
    dbGaP iPSC UUID: f88baccb5da947f5b9e4884c20396013

  • UCSD073i-1-4 ( Induced pluripotent stem cell line )

    Amnesia, thyroid problems
    dbGaP iPSC UUID: 7832f778fa394e16a9d900549e6404dc

  • UCSD074i-1-5 ( Induced pluripotent stem cell line )

    Overactive thyroid
    dbGaP iPSC UUID: 5fa443b8474c45dda96999825b76649c

  • UCSD075i-1-6 ( Induced pluripotent stem cell line )

    Non-affected Control
    dbGaP iPSC UUID: cb94c4634ea745d18549e707a36ebfe7

  • UCSD076i-1-7 ( Induced pluripotent stem cell line )

    Non-affected Control
    dbGaP iPSC UUID: fe571d08a1214ea29512fc78504d4849

  • UCSD077i-1-8 ( Induced pluripotent stem cell line )

    Non-affected Control
    dbGaP iPSC UUID: 91c2b2f30bd94bf181d375c83284ad41

  • UCSD078i-1-9 ( Induced pluripotent stem cell line )

    Non-affected Control
    dbGaP iPSC UUID: 44f1fcf10c1549f2b442e53ddf70fa7c

  • UCSD079i-1-12 ( Induced pluripotent stem cell line )

    Non-affected Control
    dbGaP iPSC UUID: fc9f310ee4c348eb93241044ac8a542c

  • UCSD080i-1-13 ( Induced pluripotent stem cell line )

    Tumor in colon
    dbGaP iPSC UUID: c27a36fe21364e5ba7160fc283bf7911

  • UCSD081i-1-14 ( Induced pluripotent stem cell line )

    Non-affected Control
    dbGaP iPSC UUID: da7063aaaab040708a61885aae4f6df9

  • UCSD082i-40-1 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: a7ba471590e64187888ddbfc3b124809

  • UCSD083i-40-2 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: 8c1dcddd184b4e62a7e1fa3407fd58cb

  • UCSD084i-6-1 ( Induced pluripotent stem cell line )

    Asthma
    dbGaP iPSC UUID: e550facf292347dda740d935a5980b55

  • UCSD085i-6-2 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: 56afbe469f9442d18c3641acfcc08b99

  • UCSD086i-6-3 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: 11c5018bc97549178e97975c9308aa0c

  • UCSD087i-6-4 ( Induced pluripotent stem cell line )

    Asthma
    dbGaP iPSC UUID: 58573de05e654bf88f207c252b8d1cce

  • UCSD088i-6-5 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: 734276c8176c49cc8557db38fa35419c

  • UCSD089i-15-1 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: 6cdb00f363dd4f749e9bd1be890246b8

  • UCSD090i-15-2 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: f6c06de6f49f4c559beff7fceaacc8de

  • UCSD091i-15-3 ( Induced pluripotent stem cell line )

    Type I Diabetes
    dbGaP iPSC UUID: ebabafed6acd4fd28d93b926cf9725f2

  • UCSD092i-1-10 ( Induced pluripotent stem cell line )

    Non-affected Control
    dbGaP iPSC UUID: 55b4f1c03ff9493999c776dda41c9e5b

  • UCSD093i-1-11 ( Induced pluripotent stem cell line )

    Non-affected Control
    dbGaP iPSC UUID: c1a0b73e2e14462696073b9c5aba7808

  • UCSD094i-25-1 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: 8a3c76df480743ad98a67eeeadcb2217

  • UCSD095i-25-2 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: 1883271f923049afaab1474fb3df3d6a

  • UCSD096i-34-1 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: 73eeae9cff9545499795ce2289384bae

  • UCSD097i-34-2 ( Induced pluripotent stem cell line )

    Hypothyroidism
    dbGaP iPSC UUID: ecd93603e54e43d7bbc5b818dd381bde

  • UCSD098i-35-1 ( Induced pluripotent stem cell line )

    GERD
    dbGaP iPSC UUID: f09a3e1ef3ff41bc93a989703c18e280

  • UCSD099i-35-2 ( Induced pluripotent stem cell line )

    Hypothyroidism, high cholesterol
    dbGaP iPSC UUID: 430fea8b9269454d9f0db226b9a676d8

  • UCSD100i-36-1 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: 2e3549799ef0461f9ea49878d69ea218

  • UCSD101i-36-2 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: 3ebafd49b3194faba1315ce779ba0899

  • UCSD102i-2-1 ( Induced pluripotent stem cell line )

    Long QT Syndrome (Type II)
    dbGaP iPSC UUID: 7da656c17c7d4f05bebd0aa20e2bdc16

  • UCSD103i-2-2 ( Induced pluripotent stem cell line )

    Long QT Syndrome
    dbGaP iPSC UUID: 47adb126a87f456b94fae30910bd1d9e

  • UCSD104i-2-3 ( Induced pluripotent stem cell line )

    Long QT Syndrome, Seizure
    dbGaP iPSC UUID: 8cf89b6100ed48dc96fac1680f3ff799

  • UCSD105i-2-4 ( Induced pluripotent stem cell line )

    Non-affected Control
    dbGaP iPSC UUID: 81975dc1298849c58487a528f99c25f3

  • UCSD106i-2-5 ( Induced pluripotent stem cell line )

    Long QT Syndrome, Seizure disorder
    dbGaP iPSC UUID: 8730a13b4957463f94e49ee2a0d99c2d

  • UCSD107i-2-6 ( Induced pluripotent stem cell line )

    Non-Hodgkin's Lymphoma
    dbGaP iPSC UUID: 1301732aae7449ee9bc665d1d41051ce

  • UCSD108i-2-7 ( Induced pluripotent stem cell line )

    Long QT Syndrome, High cholesterol
    dbGaP iPSC UUID: 4a9c0b93d8974d678559396b38e97b1f

  • UCSD109i-2-8 ( Induced pluripotent stem cell line )

    Asthma, celiac disease
    dbGaP iPSC UUID: 8160a823c38945a4ae659ab4d98e31ca

  • UCSD110i-2-9 ( Induced pluripotent stem cell line )

    Non-affected Control
    dbGaP iPSC UUID: 82f970b5d49d4b3cbd79a776c9b78eef

  • UCSD111i-2-10 ( Induced pluripotent stem cell line )

    Non-affected Control
    dbGaP iPSC UUID: 840e9950bad942b9b8104a8a15276cb9

  • UCSD112i-2-11 ( Induced pluripotent stem cell line )

    Non-affected Control
    dbGaP iPSC UUID: bd4b84099e564ca0bcf19e3f61a4de13

  • UCSD113i-68-1 ( Induced pluripotent stem cell line )

    Hypertrophic cardiomyopathy 5 years prior, ventricular arrythmias
    dbGaP iPSC UUID: 292419e565d0456fb4bb643f20c6677c

  • UCSD114i-69-1 ( Induced pluripotent stem cell line )

    Atrial fibrillation, congestive heart failure, COPD
    dbGaP iPSC UUID: 61fbcaede4f046d4b9ec9fca3b1f1afa

  • UCSD115i-70-1 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: 329475afc47e4bce8c535fb72d374150

  • UCSD116i-71-1 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: 4534e0734caf433cacaa03a270fa9bb4

  • UCSD117i-72-1 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: 754a91dca2e944f9a21b9536e2bc453d

  • UCSD118i-38-1 ( Induced pluripotent stem cell line )

    Prostate cancer previously
    dbGaP iPSC UUID: f03b06367826443a8da007a207e826aa

  • UCSD119i-38-2 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: 2acdaca106794ee78f10728eff55fd02

  • UCSD120i-39-1 ( Induced pluripotent stem cell line )

    Left ventricular non-compaction, congestive heart failure
    dbGaP iPSC UUID: 79630ab28a7d463894cc44ade50197be

  • UCSD121i-39-2 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: d0c29527bcd04ebcbc8e66276e3d02f4

  • UCSD122i-73-1 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: 736c51b084a84466a19efe23e99b95d8

  • UCSD123i-74-1 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: 049719b5bf8e489582d0d9dccf2901ea

  • UCSD124i-7-1 ( Induced pluripotent stem cell line )

    Glaucoma
    dbGaP iPSC UUID: b2c39ddc1f9f4eada3ad4324d05e4981

  • UCSD125i-7-2 ( Induced pluripotent stem cell line )

    COPD
    dbGaP iPSC UUID: b0267363e81d4d749b23690abbc5030d

  • UCSD126i-7-3 ( Induced pluripotent stem cell line )

    High cholesterol, diabetes
    dbGaP iPSC UUID: fdb193eecc1242a79e1014ed0fb854e8

  • UCSD127i-7-4 ( Induced pluripotent stem cell line )

    High cholesterol
    dbGaP iPSC UUID: 09678d311af944829d71bcdfdc37c0a1

  • UCSD128i-7-5 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: 32da9e0573734636b4297e50bf42dba2

  • UCSD129i-75-1 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: 3cc054a79bea400f8af308ff8265a5e9

  • UCSD130i-76-1 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: 3981cefd8d5d4319a2fe608ea87499fe

  • UCSD131i-77-1 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: 9a5bda14e01441119f4233d223d25763

  • UCSD132i-78-1 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: f3b46d41ae7941589a69314b2462be4d

  • UCSD133i-79-1 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: 98d311ef15b741f0be5169ce9ead7044

  • UCSD134i-80-1 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: 035af887d7c0416c9b8f7f1390f6ba8c

  • UCSD135i-81-1 ( Induced pluripotent stem cell line )

    Low thyroid, hypertension
    dbGaP iPSC UUID: 89c31202b6d64d04ab5d8608a9e21139

  • UCSD136i-82-1 ( Induced pluripotent stem cell line )

    Atrioventricular block
    dbGaP iPSC UUID: 8f0fa72886a14579adee64dc8415f682

  • UCSD137i-83-1 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: eda9efa6cda8468fb56d1f5a7a43b80b

  • UCSD138i-84-1 ( Induced pluripotent stem cell line )

    High cholesterol
    dbGaP iPSC UUID: 812d9433e25c4227bf95f9ea0852ee53

  • UCSD139i-85-1 ( Induced pluripotent stem cell line )

    Crohn's Disease
    dbGaP iPSC UUID: 40c704f28e5644c5ae729d492e0899ea

  • UCSD140i-37-1 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: 85893f770f08486aadd7aadb4ade35c4

  • UCSD141i-37-2 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: 2fde7b423484475c984d6d3dae5c1159

  • UCSD142i-86-1 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: 10a12f53eb1f4825b2b55609e0085fd4

  • UCSD143i-87-1 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: cf6f9f699cd24fc98f395151dd362f2e

  • UCSD144i-88-1 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: 39463d3b38684539a76fb9d214dffd4b

  • UCSD145i-89-1 ( Induced pluripotent stem cell line )

    Atrial fibrillation
    dbGaP iPSC UUID: 7d5dface9b574d96a2f5588e53a1a117

  • UCSD146i-10-1 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: 599828182da5493fa84eed39eac11a3a

  • UCSD147i-10-2 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: 04feea1a3844496fba12a70792a615de

  • UCSD148i-10-3 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: bb62c80354b84c08a3a348a73a184329

  • UCSD149i-10-4 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: a1b9841ecfb642c9967795961b838b02

  • UCSD150i-11-1 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: 2c61fd82f374462fbbc00eb208d2db1a

  • UCSD151i-11-2 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: 0e2317c22bd94ba09d918a5ea16a6a76

  • UCSD152i-11-3 ( Induced pluripotent stem cell line )

    Endometriosis
    dbGaP iPSC UUID: a118dd3167aa43ba9633758bfff68c4c

  • UCSD153i-11-4 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: 8f1b4e3672e643a5a16e4f733cc2c467

  • UCSD154i-90-1 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: 49e3ad187a1d4a25ba1fd1e23e0f9759

  • UCSD155i-12-1 ( Induced pluripotent stem cell line )

    Long QT Syndrome, Generalized anxiety disorder
    dbGaP iPSC UUID: 04973ac0eb5b47b98c73a568bda368e7

  • UCSD156i-12-2 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: eec852c1e04b4b95ac599f48aa76e175

  • UCSD157i-12-3 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: 0ab72627d0c545dc987c4a9b38c86c7c

  • UCSD158i-12-4 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: 1a31c8a3ee0544f5a27b23c32ce037fb

  • UCSD159i-91-1 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: 7a1ea1ca424342fdbdb84cad314a3d38

  • UCSD160i-92-1 ( Induced pluripotent stem cell line )

    Chronic sinus infections
    dbGaP iPSC UUID: 953ba56b64f3468a96657e24face28bd

  • UCSD161i-93-1 ( Induced pluripotent stem cell line )

    Diabetes mellitus, thyroid removed
    dbGaP iPSC UUID: 5e0ed1ff71fe4c509a23cfb62fa86a5e

  • UCSD162i-94-1 ( Induced pluripotent stem cell line )

    Cardiomyopathy (Hypertrophic)
    dbGaP iPSC UUID: 0c7f8f20fb8a49ab9c3ece7cee9fa3a2

  • UCSD163i-95-1 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: e38cfd59f0a543cdbc4b7e8fc2921c48

  • UCSD164i-96-1 ( Induced pluripotent stem cell line )

    Low thyroid, schizophrenia
    dbGaP iPSC UUID: 464ff0570f0a42ffadd119c0ee0f671a

  • UCSD165i-97-1 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: 3c6051059b504f36add3634021cceac8

  • UCSD166i-98-1 ( Induced pluripotent stem cell line )

    Crohn's Disease, asthma
    dbGaP iPSC UUID: 3d29f82b257f4f2f8d1c5f9a4d5ebf34

  • UCSD167i-99-1 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: 60f4798a271445509afe901c32feacc3

  • UCSD168i-22-1 ( Induced pluripotent stem cell line )

    High cholesterol
    dbGaP iPSC UUID: 6459b28f482d4bc0b2e6e3a47ce4eb4c

  • UCSD169i-22-2 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: 65b9da4ad7a646e18e901adf58bad3e6

  • UCSD170i-22-3 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: 46116d998093453dab160d6da179d76e

  • UCSD171i-100-1 ( Induced pluripotent stem cell line )

    Lyme disease
    dbGaP iPSC UUID: 61c3fda2e24c4aee81accec9fa724ca6

  • UCSD172i-101-1 ( Induced pluripotent stem cell line )

    Atrioventricular block
    dbGaP iPSC UUID: 6196047751774ff8b728ee27951667db

  • UCSD173i-18-1 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: 56f290a31980430f97e0591537e46e41

  • UCSD174i-18-2 ( Induced pluripotent stem cell line )

    Diabetes, GERD
    dbGaP iPSC UUID: 68cccf78717f405897ea79f86ef24406

  • UCSD175i-18-3 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: 05ed8fa9b5af465687af194ab6c52c6a

  • UCSD176i-17-1 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: ddc21ef7fd194fd1bcb12e83b243c9ee

  • UCSD177i-17-2 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: b3b0b16a27364ab5b6819d5300a20ce7

  • UCSD178i-17-3 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: 6ce9cf7affe746f38d2902743bf300f6

  • UCSD179i-27-1 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: 235a5deb085d45aeb17ee4289f1986e9

  • UCSD180i-27-2 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: 328569b5424c4d0d9956a340d9f76792

  • UCSD181i-3-1 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: ec609d97460e4d9f8ba76ca88a06ba0e

  • UCSD182i-3-2 ( Induced pluripotent stem cell line )

    Non-affected Control
    dbGaP iPSC UUID: 3717566eae6c4d4c88efe4af1e6af6a9

  • UCSD183i-102-1 ( Induced pluripotent stem cell line )

    High cholesterol
    dbGaP iPSC UUID: 257b1104784c4e9a91eac545853488ca

  • UCSD184i-8-1 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: 724ca23a64aa4c71a9e1cd1914c0eb47

  • UCSD185i-8-2 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: 5ee3ea91e6744724892bcf9d72aa38d7

  • UCSD186i-103-1 ( Induced pluripotent stem cell line )

    Hypothyroidism
    dbGaP iPSC UUID: 681bc182b1d24ce4bbce4dfdd04ca598

  • UCSD187i-104-1 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: 9761416eeb48417c8aa956124e18ebdc

  • UCSD188i-105-1 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: f1e1f65c500944e2a170b4ec138b0b26

  • UCSD189i-28-1 ( Induced pluripotent stem cell line )

    Asthma
    dbGaP iPSC UUID: b0b28bbf3f8d4197a52c2485c43dbd3c

  • UCSD190i-28-2 ( Induced pluripotent stem cell line )

    Hashimoto's thyroiditis
    dbGaP iPSC UUID: a1338d054c2a4830a537d23abb9264b9

  • UCSD191i-13-1 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: 5e9025929c534333bac11fd2bbf4735f

  • UCSD192i-13-2 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: 39602e3d83aa458aa130e7bcd0036afe

  • UCSD193i-106-1 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: 42c5e658e5b64fd49cd9f51ebaf4123d

  • UCSD194i-29-1 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: 0fb22f092a0043c8be99d5adb3532735

  • UCSD195i-29-2 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: f4ddb16621a84ed6a9883398048201f9

  • UCSD196i-30-1 ( Induced pluripotent stem cell line )

    Glaucoma
    dbGaP iPSC UUID: 3b5781f3a29f4adb882c5f570954828d

  • UCSD197i-30-2 ( Induced pluripotent stem cell line )

    Glaucoma
    dbGaP iPSC UUID: d81748605dd646178432e6e4e22c6bd6

  • UCSD198i-23-1 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: 452b2a71139344b582fd6a5bd7df9e84

  • UCSD199i-107-1 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: 452d8788b6f9456f8bc7fd5107243f25

  • UCSD200i-4-1 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: 19a058ec5eb6444dba3d7c93c5108577

  • UCSD201i-4-2 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: c52f8cedef0f448ea86839be9278fb41

  • UCSD202i-108-1 ( Induced pluripotent stem cell line )

    Diabetes
    dbGaP iPSC UUID: 9b01b2517732448a97ca507a14ee2d57

  • UCSD203i-109-1 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: 6a2899c945eb4151b9d991b81f036bde

  • UCSD204i-26-1 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: 86fdd69915e54bd1ac3a939251009f93

  • UCSD205i-110-1 ( Induced pluripotent stem cell line )

    Breast cancer
    dbGaP iPSC UUID: 4cf70d037dd14936beb00820611439cb

  • UCSD206i-31-1 ( Induced pluripotent stem cell line )

    Hepatitis C
    dbGaP iPSC UUID: 89f4973e18a54f6b8194f4e626aa25a3

  • UCSD207i-31-2 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: 50bcd906661a4d999b52c725ca54967f

  • UCSD208i-111-1 ( Induced pluripotent stem cell line )

    Breast cancer (DCIS)
    dbGaP iPSC UUID: bb2f4dadd5844e2fb424448f9bf97252

  • UCSD209i-24-1 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: 80cde3a454984d3c9abbe0d610e23067

  • UCSD210i-112-1 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: 08d24906ece74f2995f9b81ee5984567

  • UCSD211i-32-1 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: 4d08f157602649119d821d6954e23a5f

  • UCSD212i-32-2 ( Induced pluripotent stem cell line )

    Hypothyroidism
    dbGaP iPSC UUID: 56159fd6e4ee4ec6903035dfbee917a3

  • UCSD213i-14-1 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: 7723df7d564b4243bda170f8afc7d731

  • UCSD214i-14-2 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: 0d6f5378587d43d39ce2d54e3772bdef

  • UCSD215i-113-1 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: ffbb06de45fc4f6688764a982e306926

  • UCSD216i-114-1 ( Induced pluripotent stem cell line )

    Glaucoma
    dbGaP iPSC UUID: c98e03b8c71e4ee58f7ff970119753a8

  • UCSD217i-115-1 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: 8e038c41893e43cc937c9bdb16798af4

  • UCSD218i-116-1 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: bfcaa483134a49988cafb535e511f7d0

  • UCSD219i-117-1 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: 00d0efe1b7e1484e890fc332a1c4002b

  • UCSD220i-118-1 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: 92afe1697bcb4301a18b8b145cca5aec

  • UCSD221i-119-1 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: a47700c9a3624dc08f03b2c263ec8c17

  • UCSD222i-120-1 ( Induced pluripotent stem cell line )

    Non-affected
    dbGaP iPSC UUID: 4b22ae87b05e4292b1b72bc42793efc9

Resource Collection

  • (WiCell) QT Interval and ECG Cardiac Traits Collection - Frazer Lab ( Resource Collection )

    This collection, from Dr. Kelly Frazer (UC San Diego), was generated for regulatory genomic studies in iPS cells and derived cardiomyocytes. The iPS cell lines from these studies are included within this collection.

    This collection contains 224 cell lines, including 41 family groups within this study and 13 sets of twins. (Pedigrees are detailed in “Genetically Related Cell Lines” of each cell line’s web page.) Individuals giving rise to iPSC lines were from the UCSD Twin/Sibling/Pedigree (TSP) cohort, and were re-consented for this study. Disease states for the donors include long QT Syndrome, ECG traits (cardiac arrhythmias, sudden cardiac death), as well as individuals with no reported diagnoses. The age of donors range from 9-88 and ethnicities include European, African American, and Asian.


Web Links:

Last updated: 2017-05-19T11:26:03.387-05:00

Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016