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Steinberg Lab

eagle-i ID

http://shared.eagle-i.net/i/0000015a-166e-7a8d-49f6-255680000000

Resource Type

  1. Laboratory

Properties

  1. Resource Description
    The ability to genotype millions of polymorphisms in thousands of individuals and to sequence entire genomes affords the opportunity to understand how human diversity is associated with many diseases and longevity. It is also possible to direct the differentiation of patient-specific induced pluripotent stem cells, or iPSCs to erythroid progenitors that mature to produce hemoglobin. Both genomics and new iPSC technology can be used to study the molecular basis of phenotypic heterogeneity. This knowledge will then allow the development of predictive networks and genetic risk scores that can be used prognostically and point to functional studies of interesting variants and novel pathways that might can lead to new treatment options. We are taking this approach to the study of hemoglobin disorders focusing on sickle cell disease.
  2. PI
    Steinberg, Martin, M.D.
  3. Affiliation
    Boston University
  4. Website(s)
    http://www.bumc.bu.edu/hematology/research/martin-steinberg-md/
 
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Provenance Metadata About This Resource Record

Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016