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(WiCell) Alzheimer's Disease Collection

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Resource Type

  1. Resource Collection


  1. Resource Description
    Alzheimer’s disease pathogenesis investigation has historically been limited by difficulties in obtaining live neurons from patients and the inability to model the sporadic form of the disease. In an effort to overcome these hurdles, primary fibroblasts were isolated and reprogrammed into iPS cell lines from two patients with familial Alzheimer’s disease, both caused by a duplication of the amyloid-β precursor protein gene1 (APP; termed APPDp); two with sporadic Alzheimer’s disease (termed sAD1, sAD2); and two non-demented control individuals. A total of 19 iPS cell lines were derived from materials obtained from these individuals.
  2. Topic
    Alzheimer's disease
  3. Related Publication or Documentation
    Probing the secrets of Alzheimer's disease using human-induced pluripotent stem cell technology.
  4. Website(s)
  5. Developed by
    Goldstein Lab
Provenance Metadata About This Resource Record

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