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GM23225-iPSC

eagle-i ID

http://shared.eagle-i.net/i/00000144-8ad7-e861-5797-c9ee80000000

Resource Type

  1. Induced pluripotent stem cell line

Properties

  1. Source Developmental Stage
    Neonate stage
  2. Source Human Subject
    GM23225-HS
  3. Exchange facilitator
    <html> <a href=http://ccr.coriell.org/Sections/Search/Sample_Detail.aspx?Ref=GM23225&PgId=166><img src="http://ccr.coriell.org/Images/c_logo.jpg"></a> </html>
  4. Induction Reagents
    retrovirus
  5. Karyotype Description
    46,XX.arr(1-22,X)x2
  6. Resource Description
    HUNTINGTON DISEASE; HD Induced pluripotent stem cell line derived from GM04281 by reprogramming with lentiviral constructs encoding OCT4 (also known as POU5F1), SOX2, Klf4 and cMyc (Park et al. Cell 134:877-86, 2008); the HTT gene CAG repeat numbers for this iPSC line are 17 and 72, as determined by Coriell's Molecular Biology Laboratory. (CAG)n EXPANSION; Huntington disease is caused by expansion of a polymorphic trinucleotide repeat (CAG)n located in the coding region of the gene for huntingtin. The range of repeat numbers is 9 to 37 in normal individuals and 37 to 86 in HD patients.
  7. Access Restriction(s)
    MTA required
  8. Related Disease
    Huntington's disease
  9. Related Publication or Documentation
    Disease-Specific Induced Pluripotent Stem Cells
  10. Website(s)
    http://ccr.coriell.org/Sections/Search/Sample_Detail.aspx?Ref=GM23225&PgId=166
  11. Genetic Alteration(s)
    HD(CAG):72
  12. Source Anatomical Structure
    Zone of skin
  13. Source Organism Type
    Homo sapiens
  14. Catalog Number
    GM23225
  15. Potency
    Mesoderm
  16. Subject Age at Sampling
    20
  17. Location
    NIGMS Repository (@Coriell)
 
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Provenance Metadata About This Resource Record

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