eagle-i eagle-i Network Shared Resource Repositoryeagle-i Network Shared Resource Repository
See it in Search
This page is a preview of the following resource. Continue onto eagle-i search using the button on the right to see the full record.

Single Molecule Dwell-time Distributions

eagle-i ID

http://shared.eagle-i.net/i/0000013a-4ad1-1b9d-5291-c33f80000000

Resource Type

  1. Software

Properties

  1. Resource Description
    Dwell-time distributions, waiting-time distributions, or distributions of pause durations are widely reported in single molecule biophysical experiments. Simplified models have enabled kinetic analyses of many systems, but they may misrepresent the data if reverse and branching kinetic pathways are present. We have developed a novel computational method that overcomes these limitations and can handle complex kinetic schemes. Furthermore this method can be used to globally fit data under different conditions with a single kinetic scheme. This method was originally developed for the analysis of single molecule dwell-time distributions of myosin V under different concentrations and optical trap forces. Reference: Liao, J.-C., Spudich, J.A., Parker, D., Delp, S.L. (2007) Extending the absorbing boundary method to fit dwell-time distributions of molecular motors with complex kinetic pathways. Proceedings of the National Academy of Sciences, USA, 104, 3171-3716. http://www.pnas.org/cgi/content/abstract/104/9/3171 Keywords: computational modeling, simulation
  2. Contact
    Liao, Jung-Chi
  3. Used by
    Columbia University
  4. Operating System
    Linux
  5. Operating System
    Windows
 
RDFRDF
 
Provenance Metadata About This Resource Record

Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016